Jonathan Pugh is a Postdoctoral Research Fellow in Applied Moral Philosophy at The University of Oxford. He is currently leading a Wellcome Trust funded project entitled "The Ethics of Novel Therapeutic Applications of Deep Brain Stimulation". His research interests lie primarily in issues concerning personal autonomy in practical ethics, particularly topics pertaining to informed consent. He has also written on the ethics of human embryonic stem cell research, criminal justice, human enhancement, and gene-editing.
Neuromodulation : journal of the International Neuromodulation Society
Innovative neurosurgical treatments present a number of known risks, the natures and probabilities of which can be adequately communicated to patients via the standard procedures governing obtaining informed consent. However, due to their novelty, these treatments also come with unknown risks, which require an augmented approach to obtaining informed consent.This paper aims to discuss and provide concrete procedural guidance on the ethical issues raised by serious unexpected complications of novel deep brain stimulation treatments.We illustrate our analysis using a case study of the unexpected development of recurrent stereotyped events in patients following the use of deep brain stimulation (DBS) to treat severe chronic pain. Examining these unexpected complications in light of medical ethical principles, we argue that serious complications of novel DBS treatments do not necessarily make it unethical to offer the intervention to eligible patients. However, the difficulty the clinician faces in determining whether the intervention is in the patient's best interests generates reasons to take extra steps to promote the autonomous decision making of these patients.We conclude with clinical recommendations, including details of an augmented consent process for novel DBS treatment.
Deep Brain Stimulation, Authenticity and Value-CORRIGENDUM.
Pugh, J, Maslen, H, Savulescu, J
Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees
Exercise prescription and the doctor's duty of non-maleficence.