Human stem cell-based embryo models: A review of ethical and governance questions

UOIs Dr Jonathan Pugh and Professor Katrien Devolder have contributed to a road-map report on the ethics of human stem cell-based embryo models (SCBEMs).

The report, Human stem cell-based embryo models: A review of ethical and governance questions, was published on 27 November 2024 by The Nuffield Council on Bioethics.

This report is concerned with ethical and governance questions arising from research involving human stem cell-based embryo models (SCBEMs). As a research tool, SCBEMs have the potential to bring public benefit through new insights around early human development. However, there is debate about their status – for example in relation to human embryos – and how they should be used. The report provides an overview of the science, ethics and regulatory landscape in this new and fast-moving field. It sets out a clear road map for governance both now and in the future, whilst acknowledging areas of uncertainty. It details the considerations of the working group and the principles and rationale for how conclusions have been reached, with the aim of offering a useful resource to policymakers, scientists and research funders, and forming the basis of further discussion and decision making in this fast-moving area.

The full report and policy briefing document are available to view/download here