Report: 'The Ethics of Controlled Human Infection Model Studies for Mitigating Pandemic Risks'
'The Ethics of Controlled Human Infection Model Studies for Mitigating Pandemic Risks'
Report commissioned by 1Day Sooner (March 2023)
Authors: Bridget Williams, Josh Morrison, Dominic Wilkinson, Julian Savulescu
This report provides guidance on when it may be appropriate to conduct CHIM studies and the requirements for their ethical conduct. This includes guidance on conducting CHIM studies prior to an outbreak and at the beginning of an outbreak with a known PPP or novel pathogen that may have pandemic potential. The report has been developed for the context of the UK. It aims to inform UK policymakers, researchers, regulators, and members of research ethics committees.
1Day Sooner aims to reduce the global burden on infectious disease and avert future pandemics by working to accelerate the development and implementation of vaccines, treatments, and mechanical interventions. They do so as advocates for people who want to be in high-impact medical studies, including human challenge studies.